[HTML][HTML] Characterization of aggrecan retained and lost from the extracellular matrix of articular cartilage: involvement of carboxyl-terminal processing in the catabolism …
MZ Ilic, HC Robinson, CJ Handley - Journal of Biological Chemistry, 1998 - ASBMB
The catabolism of aggrecan in bovine articular cartilage explants is characterized by the
release into the culture medium of high molecular weight aggrecan fragments, generated by
the proteolytic cleavage of the core protein between residues Glu 373 and Ala 374 within the
interglobular domain. In this study, the position of the carboxyl–terminus of these aggrecan
fragments, as well as a major proteolytically shortened aggrecan core protein present in
cartilage matrix, have been deduced by characterizing the peptides generated by the …
release into the culture medium of high molecular weight aggrecan fragments, generated by
the proteolytic cleavage of the core protein between residues Glu 373 and Ala 374 within the
interglobular domain. In this study, the position of the carboxyl–terminus of these aggrecan
fragments, as well as a major proteolytically shortened aggrecan core protein present in
cartilage matrix, have been deduced by characterizing the peptides generated by the …
