Increased levels of soluble adhesion molecules in the serum of patients with Hepatitis C (Correlation with Cytokine Concentrations and Liver Inflammation and …
G Kaplanski, C Farnarier, MJ Payan… - Digestive diseases and …, 1997 - Springer
G Kaplanski, C Farnarier, MJ Payan, P Bongrand, JM Durand
Digestive diseases and sciences, 1997•SpringerLymphocyte adhesion to endothelium, extravasation, and adhesion to hepatocytes are
mediatedby adhesion molecules and constitute important steps inthe liver inflammation due
to chronic hepatitis C (HCV-CH). We measured soluble intercellular adhesionmolecule
(sICAM-1, sCD54), vascular cell adhesionmolecule (sVCAM-1, sCD106), E-selectin
(sCD62E), as wellas interleukin (IL)-1β, IL-8, and tumor necrosis factor-α (TNF-α)
concentrations inthe serum of 22 patients with HCV-CH in comparison to 20seronegative …
mediatedby adhesion molecules and constitute important steps inthe liver inflammation due
to chronic hepatitis C (HCV-CH). We measured soluble intercellular adhesionmolecule
(sICAM-1, sCD54), vascular cell adhesionmolecule (sVCAM-1, sCD106), E-selectin
(sCD62E), as wellas interleukin (IL)-1β, IL-8, and tumor necrosis factor-α (TNF-α)
concentrations inthe serum of 22 patients with HCV-CH in comparison to 20seronegative …
Abstract
Lymphocyte adhesion to endothelium,extravasation, and adhesion to hepatocytes are mediatedby adhesion molecules and constitute important steps inthe liver inflammation due to chronic hepatitis C(HCV-CH). We measured soluble intercellular adhesionmolecule (sICAM-1, sCD54), vascular cell adhesionmolecule (sVCAM-1, sCD106), E-selectin (sCD62E), as wellas interleukin (IL)-1β, IL-8, and tumor necrosis factor-α (TNF-α) concentrations inthe serum of 22 patients with HCV-CH in comparison to 20seronegative healthy volunteers. sICAM-1, sVCAM-1,sCD62E, TNF-α, and IL-8 but not IL-1βconcentrations were significantly elevated in patients.sICAM-1 and sCD62E correlated with TNF-α andaspartate amino transferases levels. sICAM-1 correlatedwith liver lobular inflammation whereas sVCAM-1, sCD62E, and IL-8 correlated with liver fibrosis.Measurement of soluble adhesion molecules may be an easyway to follow liver inflammation and fibrosis duringHCV-CH.
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