[HTML][HTML] CREB is a regulatory target for the protein kinase Akt/PKB
K Du, M Montminy - Journal of Biological Chemistry, 1998 - ASBMB
The nuclear factor CREB stimulates the expression of cellular genes following its protein
kinase A-mediated phosphorylation at Ser-133. Ser-133 phosphorylation, in turn, activates
target gene expression by promoting recruitment of the co-activator CBP. Recent studies
showing that CREB and its paralog CREM are required for survival of certain cell types
prompted us to examine whether CREB is a nuclear target for activation via the growth factor-
dependent Ser/Thr kinase Akt/PKB. When overexpressed in serum-stimulated cells, Akt/PKB …
kinase A-mediated phosphorylation at Ser-133. Ser-133 phosphorylation, in turn, activates
target gene expression by promoting recruitment of the co-activator CBP. Recent studies
showing that CREB and its paralog CREM are required for survival of certain cell types
prompted us to examine whether CREB is a nuclear target for activation via the growth factor-
dependent Ser/Thr kinase Akt/PKB. When overexpressed in serum-stimulated cells, Akt/PKB …