[HTML][HTML] The PDZ protein tax-interacting protein-1 inhibits β-catenin transcriptional activity and growth of colorectal cancer cells
M Kanamori, P Sandy, S Marzinotto, R Benetti… - Journal of Biological …, 2003 - ASBMB
Wnt signaling is essential during development while deregulation of this pathway frequently
leads to the formation of various tumors including colorectal carcinomas. A key component
of the pathway is β-catenin that, in association with TCF-4, directly regulates the expression
of Wnt-responsive genes. To identify novel binding partners of β-catenin that may control its
transcriptional activity, we performed a mammalian two-hybrid screen and isolated the Tax-
interacting protein (TIP-1). The in vivo complex formation between β-catenin and TIP-1 was …
leads to the formation of various tumors including colorectal carcinomas. A key component
of the pathway is β-catenin that, in association with TCF-4, directly regulates the expression
of Wnt-responsive genes. To identify novel binding partners of β-catenin that may control its
transcriptional activity, we performed a mammalian two-hybrid screen and isolated the Tax-
interacting protein (TIP-1). The in vivo complex formation between β-catenin and TIP-1 was …