[HTML][HTML] TRIM32 protein sensitizes cells to tumor necrosis factor (TNFα)-induced apoptosis via its RING domain-dependent E3 ligase activity against X-linked inhibitor …
YS Ryu, Y Lee, KW Lee, CY Hwang, JS Maeng… - Journal of Biological …, 2011 - ASBMB
TRIM32, which belongs to the tripartite motif (TRIM) protein family, has the RING finger, B-
box, and coiled-coil domain structures common to this protein family, along with an
additional NHL domain at the C terminus. TRIM32 reportedly functions as an E3 ligase for
actin, a protein inhibitor of activated STAT y (PIASy), dysbindin, and c-Myc, and it has been
associated with diseases such as muscular dystrophy and epithelial carcinogenesis. Here,
we identify a new substrate of TRIM32 and propose a mechanism through which TRIM32 …
box, and coiled-coil domain structures common to this protein family, along with an
additional NHL domain at the C terminus. TRIM32 reportedly functions as an E3 ligase for
actin, a protein inhibitor of activated STAT y (PIASy), dysbindin, and c-Myc, and it has been
associated with diseases such as muscular dystrophy and epithelial carcinogenesis. Here,
we identify a new substrate of TRIM32 and propose a mechanism through which TRIM32 …