[HTML][HTML] Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein …
A Grefhorst, BM Elzinga, PJ Voshol, T Plo, T Kok… - Journal of Biological …, 2002 - ASBMB
The oxysterol-activated liver X receptor (LXR) provides a link between sterol and fatty acid
metabolism; activation of LXR induces transcription of lipogenic genes. This study shows
that induction of the lipogenic genes Srebp-1c, Fas, and Acc1 upon administration of the
synthetic LXR agonist T0901317 to C57BL/6J mice (10 mg/kg/day, 4 days) is associated
with massive hepatic steatosis along the entire liver lobule and a 2.5-fold increase in very
low density lipoprotein-triglyceride (VLDL-TG) secretion. The increased VLDL-TG secretion …
metabolism; activation of LXR induces transcription of lipogenic genes. This study shows
that induction of the lipogenic genes Srebp-1c, Fas, and Acc1 upon administration of the
synthetic LXR agonist T0901317 to C57BL/6J mice (10 mg/kg/day, 4 days) is associated
with massive hepatic steatosis along the entire liver lobule and a 2.5-fold increase in very
low density lipoprotein-triglyceride (VLDL-TG) secretion. The increased VLDL-TG secretion …