[HTML][HTML] Ataxia telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthase
WC Liao, A Haimovitz-Friedman, RS Persaud… - Journal of Biological …, 1999 - ASBMB
DNA double-stranded breaks (dsb) activate surveillance systems that identify DNA damage
and either initiate repair or signal cell death. Failure of cells to undergo appropriate death in
response to DNA damage leads to misrepair, mutations, and neoplastic transformation.
Pathways linking DNA dsb to reproductive or apoptotic death are virtually unknown. Here we
report that metabolic incorporation of 125 I-labeled 5-iodo-2′ deoxyuridine, which
produces DNA dsb, signaled de novo ceramide synthesis by post-translational activation of …
and either initiate repair or signal cell death. Failure of cells to undergo appropriate death in
response to DNA damage leads to misrepair, mutations, and neoplastic transformation.
Pathways linking DNA dsb to reproductive or apoptotic death are virtually unknown. Here we
report that metabolic incorporation of 125 I-labeled 5-iodo-2′ deoxyuridine, which
produces DNA dsb, signaled de novo ceramide synthesis by post-translational activation of …