[HTML][HTML] Endocytosis of apolipoprotein AV by members of the low density lipoprotein receptor and the VPS10p domain receptor families
SK Nilsson, S Christensen, MK Raarup… - Journal of biological …, 2008 - ASBMB
Apolipoprotein AV (apoA-V) is present in low amounts in plasma and has been found to
modulate triacylglycerol levels in humans and in animal models. ApoA-V displays affinity for
members of the low density lipoprotein receptor (LDL-R) gene family, known as the classical
lipoprotein receptors, including LRP1 and SorLA/LR11. In addition to LDL-A binding
repeats, the mosaic receptor SorLA/LR11 also possesses a Vps10p domain. Here we show
that apoA-V also binds to sortilin, a receptor from the Vsp10p domain gene family that lacks …
modulate triacylglycerol levels in humans and in animal models. ApoA-V displays affinity for
members of the low density lipoprotein receptor (LDL-R) gene family, known as the classical
lipoprotein receptors, including LRP1 and SorLA/LR11. In addition to LDL-A binding
repeats, the mosaic receptor SorLA/LR11 also possesses a Vps10p domain. Here we show
that apoA-V also binds to sortilin, a receptor from the Vsp10p domain gene family that lacks …