Background Melanoma is a complex multigenic disease, susceptibility to which is
determined by several parallel and stepwise progressive pathways affecting growth control,
differentiation, cell adhesion, and survival. Melanoma and human cancers in general
undergo a continuous development from benign to malignant states, as most thoroughly
documented in the multistep mole-to-melanoma transition. Objective To examine how high-
throughput microarrays are being used in expression profiling to identify regulated genes …