[HTML][HTML] Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 …
Classical mitogen-activated protein (MAP) kinases are activated by dual phosphorylation of
the Thr-Xxx-Tyr motif in their activation loop, which is catalyzed by members of the MAP
kinase kinase family. The atypical MAP kinases extracellular signal-regulated kinase 3
(ERK3) and ERK4 contain a single phospho-acceptor site in this segment and are not
substrates of MAP kinase kinases. Previous studies have shown that ERK3 and ERK4 are
phosphorylated on activation loop residue Ser-189/Ser-186, resulting in their catalytic …
the Thr-Xxx-Tyr motif in their activation loop, which is catalyzed by members of the MAP
kinase kinase family. The atypical MAP kinases extracellular signal-regulated kinase 3
(ERK3) and ERK4 contain a single phospho-acceptor site in this segment and are not
substrates of MAP kinase kinases. Previous studies have shown that ERK3 and ERK4 are
phosphorylated on activation loop residue Ser-189/Ser-186, resulting in their catalytic …