Enhanced CD8 T cell cross-presentation by macrophages with targeted disruption of STAT3
J Brayer, F Cheng, H Wang, P Horna, I Vicente-Suarez… - Immunology letters, 2010 - Elsevier
CD8 T cell tolerance, once thought to be largely a result of clonal deletion, is now
appreciated to be much more complex, additionally involving multiple permutations of partial
loss of effector function in residual clonal populations. This is especially important in the
context of tumor immunity, in which persistent tolerized cytotoxic CD8 T cells (CTL), if
reactivated, could potentially mount a protective response. Previously we have shown that
antigen-presenting cells (APCs) with a targeted disruption of STAT3 break tolerance in CD4 …
appreciated to be much more complex, additionally involving multiple permutations of partial
loss of effector function in residual clonal populations. This is especially important in the
context of tumor immunity, in which persistent tolerized cytotoxic CD8 T cells (CTL), if
reactivated, could potentially mount a protective response. Previously we have shown that
antigen-presenting cells (APCs) with a targeted disruption of STAT3 break tolerance in CD4 …