Severe tumor lysis syndrome following splenic irradiation
T Schifter, A Cohen, UH Lewinski - American journal of …, 1999 - Wiley Online Library
T Schifter, A Cohen, UH Lewinski
American journal of hematology, 1999•Wiley Online LibraryA 72‐year‐old man suffering from non‐Hodgkin's lymphoma is described. After failing to
respond to chlorambucil–prednisone regimen for three months, he was treated by splenic
irradiation (total dose 500 cGY) in 10 consecutive daily doses. Two days after the last
irradiation, the patient developed acute tumor lysis syndrome (TLS) with extreme blood
levels of uric acid (33.7 mg/dl), phosphorus (13.7 mg/dl), potassium (6.08 mEq/l), and
calcium (6.8 mg/dl). It should be remembered that the acute TLS, which usually occurs …
respond to chlorambucil–prednisone regimen for three months, he was treated by splenic
irradiation (total dose 500 cGY) in 10 consecutive daily doses. Two days after the last
irradiation, the patient developed acute tumor lysis syndrome (TLS) with extreme blood
levels of uric acid (33.7 mg/dl), phosphorus (13.7 mg/dl), potassium (6.08 mEq/l), and
calcium (6.8 mg/dl). It should be remembered that the acute TLS, which usually occurs …
Abstract
A 72‐year‐old man suffering from non‐Hodgkin's lymphoma is described. After failing to respond to chlorambucil–prednisone regimen for three months, he was treated by splenic irradiation (total dose 500 cGY) in 10 consecutive daily doses. Two days after the last irradiation, the patient developed acute tumor lysis syndrome (TLS) with extreme blood levels of uric acid (33.7 mg/dl), phosphorus (13.7 mg/dl), potassium (6.08 mEq/l), and calcium (6.8 mg/dl). It should be remembered that the acute TLS, which usually occurs following chemotherapy, can also be radiation‐induced. Am. J. Hematol. 60:75–76, 1999. © 1999 Wiley‐Liss, Inc.
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