Fibroblast growth factor-2 gene delivery stimulates axon growth by adult retinal ganglion cells after acute optic nerve injury
PS Sapieha, M Peltier, KG Rendahl… - Molecular and Cellular …, 2003 - Elsevier
Basic fibroblast growth factor (or FGF-2) has been shown to be a potent stimulator of retinal
ganglion cell (RGC) axonal growth during development. Here we investigated if FGF-2
upregulation in adult RGCs promoted axon regrowth in vivo after acute optic nerve injury.
Recombinant adeno-associated virus (AAV) was used to deliver the FGF-2 gene to adult
RGCs providing a sustained source of this neurotrophic factor. FGF-2 gene transfer led to a
10-fold increase in the number of axons that extended past 0.5 mm from the lesion site …
ganglion cell (RGC) axonal growth during development. Here we investigated if FGF-2
upregulation in adult RGCs promoted axon regrowth in vivo after acute optic nerve injury.
Recombinant adeno-associated virus (AAV) was used to deliver the FGF-2 gene to adult
RGCs providing a sustained source of this neurotrophic factor. FGF-2 gene transfer led to a
10-fold increase in the number of axons that extended past 0.5 mm from the lesion site …