ATP depletion increases tyrosine phosphorylation of β-catenin and plakoglobin in renal tubular cells
JH Schwartz, T Shih, SA Menza… - Journal of the American …, 1999 - journals.lww.com
This study examines the hypothesis that the loss of integrity of the junctional complex
induced by ATP depletion is related to alterations in tyrosine phosphorylation of the
adherens junction proteins β-catenin and plakoglobin. ATP depletion of cultured mouse
proximal tubular (MPT) cells induces a marked increase in tyrosine phosphorylation of both
β-catenin and plakoglobin. The tyrosine phosphatase inhibitor vanadate has the same effect
in ATP-replete (control) monolayers, whereas genistein, a tyrosine kinase inhibitor, reduces …
induced by ATP depletion is related to alterations in tyrosine phosphorylation of the
adherens junction proteins β-catenin and plakoglobin. ATP depletion of cultured mouse
proximal tubular (MPT) cells induces a marked increase in tyrosine phosphorylation of both
β-catenin and plakoglobin. The tyrosine phosphatase inhibitor vanadate has the same effect
in ATP-replete (control) monolayers, whereas genistein, a tyrosine kinase inhibitor, reduces …