Identification and characterization of a prostaglandin transporter

N Kanai, R Lu, JA Satriano, Y Bao, AW Wolkoff… - Science, 1995 - science.org
N Kanai, R Lu, JA Satriano, Y Bao, AW Wolkoff, VL Schuster
Science, 1995science.org
Carrier-mediated prostaglandin transport has been postulated to occur in many tissues. On
the basis of sequence homology, the protein of unknown function encoded by the rat matrin
F/G complementary DNA was predicted to be an organic anion transporter. Expression of
the matrin F/G complementary DNA in HeLa cells or Xenopus oocytes conferred the property
of specific transport of prostaglandins. The tissue distribution of matrin F/G messenger RNA
and the sensitivity of matrin F/G-induced prostaglandin transport to inhibitors were similar to …
Carrier-mediated prostaglandin transport has been postulated to occur in many tissues. On the basis of sequence homology, the protein of unknown function encoded by the rat matrin F/G complementary DNA was predicted to be an organic anion transporter. Expression of the matrin F/G complementary DNA in HeLa cells or Xenopus oocytes conferred the property of specific transport of prostaglandins. The tissue distribution of matrin F/G messenger RNA and the sensitivity of matrin F/G-induced prostaglandin transport to inhibitors were similar to those of endogenous prostaglandin transport. The protein encoded by the matrin F/G complementary DNA is thus preferably called PGT because it is likely to function as a prostaglandin transporter.
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