Epidermal growth factor receptor transactivation by the cannabinoid receptor (CB1) and transient receptor potential vanilloid 1 (TRPV1) induces differential responses …

H Yang, Z Wang, JE Capo-Aponte, F Zhang… - Experimental eye …, 2010 - Elsevier
Corneal epithelial injury induces release of endogenous metabolites that are cannabinoid
receptor 1 (CB1) and transient receptor potential vanilloid 1 (TRPV1) agonists. We
determined the functional contributions by CB1 and TRPV1 activation to eliciting responses
underlying wound healing in human corneal epithelial cells (HCEC). Both the selective CB1
and TRPV1 agonists (ie, WIN55, 212-2 [WIN] and capsaicin [CAP], respectively) induced
EGFR phosphorylation whereas either inhibition of its tyrosine kinase activity with AG1478 …