The management of early-stage and metastatic triple-negative breast cancer: a review
PR, and HER2 by immunohistochemistry (IHC), TNBC comprises approximately 15% of
incident breast cancers and is over-represented among those with metastatic disease. 2–4
TNBC is usually high grade, more often an interval breast cancer (ie, diagnosed between
screening mammograms), and, when recurrent, preferentially relapses in visceral sites, such
as lungs, liver, and brain. 4–6 Given the higher rates of recurrence and lack of traditional
targets (such as ER and HER2), treating those with TNBC evokes anxiety on the parts of …
incident breast cancers and is over-represented among those with metastatic disease. 2–4
TNBC is usually high grade, more often an interval breast cancer (ie, diagnosed between
screening mammograms), and, when recurrent, preferentially relapses in visceral sites, such
as lungs, liver, and brain. 4–6 Given the higher rates of recurrence and lack of traditional
targets (such as ER and HER2), treating those with TNBC evokes anxiety on the parts of …