IL-10 from marginal zone precursor B cells controls the differentiation of Th17, Tfh and Tfr cells in transplantation tolerance
B cells are known to control CD4T cell differentiation in secondary lymphoid tissues. We
hypothesized that IL-10 expression by marginal zone precursor (MZP) regulatory B cells
controls the differentiation and positioning of effector and regulatory T cells during
tolerization. Costimulatory blockade with donor-specific transfusion (DST) and anti-CD40L
mAb in C57BL/6 mice induced tolerance to allogeneic cardiac allograft. B cell depletion or IL-
10 deficiency in B cells prevented tolerance, resulting in decreased follicular regulatory …
hypothesized that IL-10 expression by marginal zone precursor (MZP) regulatory B cells
controls the differentiation and positioning of effector and regulatory T cells during
tolerization. Costimulatory blockade with donor-specific transfusion (DST) and anti-CD40L
mAb in C57BL/6 mice induced tolerance to allogeneic cardiac allograft. B cell depletion or IL-
10 deficiency in B cells prevented tolerance, resulting in decreased follicular regulatory …