Possible mechanism of the preventive effect of BCG against diabetes mellitus in NOD mouse: II. Suppression of pathogenesis by macrophage transfer from BCG …
H Yagi, M Matsumoto, Y Kishimoto, S Making… - Cellular …, 1991 - Elsevier
Our previous reports showed that a single injection of live BCG, one of the biological
response modifiers, prevents insulitis and overt diabetes in NOD mice and that the
suppression could be due to the generation of some type of suppressor cells in the BCG-
treated mice. Furthermore, a more recent study has revealed that macrophages suppressive
against a variety of lymphocyte functions can be induced by BCG, which suggests that these
macrophages are involved in the suppression of the pathogenesis. To obtain valid evidence …
response modifiers, prevents insulitis and overt diabetes in NOD mice and that the
suppression could be due to the generation of some type of suppressor cells in the BCG-
treated mice. Furthermore, a more recent study has revealed that macrophages suppressive
against a variety of lymphocyte functions can be induced by BCG, which suggests that these
macrophages are involved in the suppression of the pathogenesis. To obtain valid evidence …
