[HTML][HTML] MCP-1-induced human osteoclast-like cells are tartrate-resistant acid phosphatase, NFATc1, and calcitonin receptor-positive but require receptor activator of …
MS Kim, CJ Day, CI Selinger, CL Magno… - Journal of Biological …, 2006 - ASBMB
MCP-1 (monocyte chemotactic protein-1) is a CC chemokine that is induced by receptor
activator of NFκB ligand (RANKL) in human osteoclasts. In the absence of RANKL, treatment
of human peripheral blood mononuclear cells with macrophage colony-stimulating factor
and MCP-1 resulted in tartrate-resistant acid phosphatase (TRAP)-positive multinuclear cells
that are positive for calcitonin receptor (CTR) and a number of other osteoclast markers,
including nuclear factor of activated t cells, cytoplasmic, calcineurin-dependent 1 (NFATc1) …
activator of NFκB ligand (RANKL) in human osteoclasts. In the absence of RANKL, treatment
of human peripheral blood mononuclear cells with macrophage colony-stimulating factor
and MCP-1 resulted in tartrate-resistant acid phosphatase (TRAP)-positive multinuclear cells
that are positive for calcitonin receptor (CTR) and a number of other osteoclast markers,
including nuclear factor of activated t cells, cytoplasmic, calcineurin-dependent 1 (NFATc1) …
