Peroxisome proliferator-activated receptor γ: innate protection from excessive fibrogenesis and potential therapeutic target in systemic sclerosis
Current opinion in rheumatology, 2010•journals.lww.com
Drugs targeting the PPARγ pathway might be effective for the control of fibrosis as well as
pathological vascular remodeling underlying PAH and, therefore, might have a therapeutic
potential in SSc. A greater understanding of the mechanisms underlying the antifibrogenic
and vascular remodeling activities of PPARγ ligands will be necessary in order to advance
these drugs into clinical use.
pathological vascular remodeling underlying PAH and, therefore, might have a therapeutic
potential in SSc. A greater understanding of the mechanisms underlying the antifibrogenic
and vascular remodeling activities of PPARγ ligands will be necessary in order to advance
these drugs into clinical use.
Summary
Drugs targeting the PPARγ pathway might be effective for the control of fibrosis as well as pathological vascular remodeling underlying PAH and, therefore, might have a therapeutic potential in SSc. A greater understanding of the mechanisms underlying the antifibrogenic and vascular remodeling activities of PPARγ ligands will be necessary in order to advance these drugs into clinical use.
Lippincott Williams & Wilkins