Platelet-derived growth factor-induced severe and chronic vasoconstriction of cerebral arteries: proposed growth factor explanation of cerebral vasospasm
ZW Zhang, H Yanamoto, I Nagata, S Miyamoto… - …, 2010 - journals.lww.com
OBJECTIVE: After subarachnoid hemorrhage (SAH), platelet-derived growth factor-BB
(PDGF-BB) is secreted in and around the cerebral arteries. To clarify the role of PDGF-BB in
the development of vasospasm after SAH, we determined whether PDGF-BB alone can
cause long-lasting vasoconstriction of a severity similar to that of vasospasm. In addition, the
anti-vasospastic effect of trapidil, an antagonist of PDGF-BB function, was investigated.
METHODS: We infused recombinant PDGF-BB (10 μg/mL saline as the vehicle)(n= 14) into …
(PDGF-BB) is secreted in and around the cerebral arteries. To clarify the role of PDGF-BB in
the development of vasospasm after SAH, we determined whether PDGF-BB alone can
cause long-lasting vasoconstriction of a severity similar to that of vasospasm. In addition, the
anti-vasospastic effect of trapidil, an antagonist of PDGF-BB function, was investigated.
METHODS: We infused recombinant PDGF-BB (10 μg/mL saline as the vehicle)(n= 14) into …