Background Ichthyoses are a group of rare skin disorders lacking effective treatments.
Although genetic mutations are progressively delineated, comprehensive molecular
phenotyping of ichthyotic skin could suggest much-needed pathogenesis-based therapy.
Objective We sought to profile the molecular fingerprint of the most common orphan
ichthyoses. Methods Gene, protein, and serum studies were performed on skin and blood
samples from 29 patients (congenital ichthyosiform erythroderma, n= 9; lamellar ichthyosis …