[HTML][HTML] Constitutive and regulated endocytosis of the glycine transporter GLYT1b is controlled by ubiquitination
E Fernández-Sánchez, J Martínez-Villarreal… - Journal of Biological …, 2009 - ASBMB
The glycine transporter GLYT1 regulates both glycinergic and glutamatergic
neurotransmission by controlling the reuptake of glycine at synapses. Trafficking of GLYT1 to
and from the cell surface is critical for its function. Activation of PKC down-regulates the
activity of GLYT1 through a mechanism that has so far remained uncharacterized. Here we
show that GLYT1b undergoes fast constitutive endocytosis that is accelerated by phorbol
esters. Both constitutive and regulated endocytosis occur through a dynamin 2-and clathrin …
neurotransmission by controlling the reuptake of glycine at synapses. Trafficking of GLYT1 to
and from the cell surface is critical for its function. Activation of PKC down-regulates the
activity of GLYT1 through a mechanism that has so far remained uncharacterized. Here we
show that GLYT1b undergoes fast constitutive endocytosis that is accelerated by phorbol
esters. Both constitutive and regulated endocytosis occur through a dynamin 2-and clathrin …